Double Blue does not possess many standout qualities. Most combos involving Double Bloons are more efficient with other types, and an unbuffed Double Blue does less damage than a normal Yellow Bloon, while effectively taking twice the damage as a normal bloon would. It can deal decent damage if buffed, such as with Zany Juice or Booster Bloon.
Double Red Bloon can survive one Spike Storm! and is 1 gold cheaper. Double Blue can survive two Spike Storms on Dark Castle, and one shot from Bionic Boomerang, but both cards are generally poor at surviving versus an even decently prepared opponent.
For combo decks using Quick Ready, Double Yellow Bloon costs the same as Double Blue + Fortify with the same HP, but grants 2 extra Bloontonium without needing an extra card. Double Green Bloon with Eerie Lifeforce while costing more, has a much higher amount of potential damage as a finisher due to Eerie’s scaling.
Double Blue in general is not worth putting in a deck almost ever due to its very low health and subpar damage both in Aggro and in OTK strategies.