Toxic Bloon encourages opponents to avoid entirely relying on Monkeys to do the final pop. Additionally, it can punish Monkeys with random attacks, especially Arcane Master and The Big One, as they have no control over which bloon they hit.
Heroes and Powers aren't affected by Toxic Bloon. Quincy and Obyn Greenfoot are reliable ways to do the final pop without Toxic Bloon's tower-removal penalty, and an active Adora passive will break apart a leaking Toxic Bloon.
If there are no attacks available besides monkeys, use the Monkeys to deal enough damage such that the Toxic Bloon does not get popped by one of them before it leaks, unless you are going to replace the monkey you are dealing the final pop with anyway (such as with Expert Negotiator). Note that defenders will attack a leaking Toxic Bloon if they have remaining ammo, so either use up all of their ammo on other Bloons or use Whoops to protect them.
If there's many bloons mixed with Toxic Bloons and Super Monkey Storm is unavailable, Thunder Druid can be played, and then it can directly attack Toxic Bloon to remove itself.
Compared to Power-based Monkey removals, Toxic Bloon with its 1 charge is mostly a waste of space in the deck, as it doesn't offer much pressure or resource gains, and the removal function can be unreliable.
Low cost Monkeys don’t matter as much if they are removed by Toxic Bloon. For example, removing one Monkey from Barrel of Monkeys doesn’t matter in almost any circumstance.
Advanced
Classic
4
Destroying a Toxic Bloon with a Hero ability will no longer play the removal effect on the Hero
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Toxic Bloon in-game
Toxic Bloon deleting an attacking Monkey
