Bloon Embiggen on multiple cheap bloons provide the greatest value of this card. If used on swarms of 0-delay bloon cards, Bloon Embiggen can act as a finisher, or increase damage done by a good amount.
If possible, use Bloon Embiggen onto swarms of Bloons on the turn just before they leak, instead of during the same turn, in case the opponent could afford a board clear.
Red Bloon Storm takes advantage of the Bloon Embiggen's health boost. If the Reds remain undamaged, a full Red Bloon Storm is a complete OTK. This is very risky however, and is generally not recommended to try due to the high cost and slow speed of Red Bloon Storm.
In an Amelia deck, the player can use the Bloontonium from swarm Bloons on Act of Power to play this card for free. This makes it a very solid choice in Amelia Aggro decks.