MOAB Strike is used similarly to Bloon Strike, although there are more cost efficient ways to deal the same amount of damage or more to the enemy Hero. A Pink Bloon usually does the job, if not accounting for Defenders, enemy Quincy's passive, Adora's passive, or Hero Protection, for 3 less Gold, and additionally gains the benefit of +5 health when playing in Dark Castle. Two Bloon Strikes cost 1 less Gold in total. Quick Ready costs 1 less Gold and can potentially move a higher damaging Bloon to zero delay.
However, using Amelia the Amazing's Act of Power to lower the cost of this card to 3 Gold can make it more efficient in some situations.