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In decks that run a lot of Bloontonium generation, this is a cheap removal option for weak Bloons with special gimmicks, such as Toxic Bloons, Buddy Bloons, Steady Growth Bloons, and weaker Double Attack Bloons. It can also finish off stronger Bloons after chipping them with other damage sources like Mass Detonation.
In The Eternal decks, this card can instantly destroy the first-stage Eternal. It can also be used on damaged Eternals with 100 or less health, if the opponent tries to leak it.
Overload is also a good option against bloons with armored, especially Lead Coating Bloon.