Compared to the Tack Shooter, the Tack Sprayer costs twice as much, has more ammo, and deals more damage (total of 50 when defending). Therefore, it synergizes better with ATK buffs, such as Gwendolin's Heat It Up, Zee Jay's Rad Enhancements, and nearby Monkey Villages. However, it has 3 reload instead of 2.
Tack Sprayer is significantly cheaper than Elite Defender and has the same ATK when defending, but has less ammo and thus benefits less from ATK buffs.
Zee Jay aggro may use Tack Sprayer as anti-aggro, particularly against Blooming Bloon and Precursor Bloon. Compared to Robo Monkey, Sprayer can spread its damage among more Bloons, and it can reload, but it does less damage to a single target.